Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891800 | 0.84 | GRM2 (0.63) | GRM2SHMT2ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL6891440 | 0.83 | GRM2 (0.49) | GRM2ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL6894128 | 0.82 | GRM2 (0.45) | GRM2ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL1503038 | 0.82 | GRM2 (0.61) | GRM2LMNAKMT2AMAPTNPSR1 | |
| SCHEMBL1502968 | 0.81 | GRM2 (0.64) | GRM2ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL1502926 | 0.81 | GRM2 (0.64) | GRM2ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL1502974 | 0.81 | GRM2 (0.64) | GRM2ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL6891162 | 0.77 | GRM2 (0.50) | GRM2ALDH1A1KMT2ATP53HSD17B10 | |
| SCHEMBL1502970 | 0.73 | GRM2 (0.50) | GRM2ALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL6890122 | 0.72 | GRM2 (0.69) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |