Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PARG | Q86W56 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503038 | 0.89 | GRM2 (0.61) | GRM2TSHRLMNAMAPTPARG | |
| SCHEMBL6891162 | 0.88 | GRM2 (0.50) | GRM2ALDH1A1TSHRPARGHSD17B10 | |
| SCHEMBL1502968 | 0.88 | GRM2 (0.64) | GRM2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL1502926 | 0.88 | GRM2 (0.64) | GRM2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL1502974 | 0.88 | GRM2 (0.64) | GRM2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL6891830 | 0.83 | GRM2 (0.45) | GRM2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL6891306 | 0.81 | GRM2 (0.52) | GRM2ALDH1A1TSHRPARGSMN1; SMN2 | |
| SCHEMBL6893791 | 0.81 | GRM2 (0.52) | GRM2ALDH1A1TSHRPARGSMN1; SMN2 | |
| SCHEMBL6892255 | 0.81 | GRM2 (0.52) | GRM2ALDH1A1TSHRPARGSMN1; SMN2 | |
| SCHEMBL1503122 | 0.78 | ALDH1A1 (0.46) | GRM2ALDH1A1TSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |