Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892057 | 0.91 | HSP90AA1 (0.37) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6776238 | 0.90 | CD38 (0.38) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6894723 | 0.89 | MAPT (0.45) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6894986 | 0.89 | HSP90AA1 (0.38) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6888996 | 0.88 | TSHR (0.46) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6894500 | 0.88 | PTGDR2 (0.39) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6892764 | 0.88 | LMNA (0.44) | HSP90AA1HSP90B1ALDH1A1MEN1KMT2A | |
| SCHEMBL6890571 | 0.88 | MAPT (0.45) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6894814 | 0.87 | MAPT (0.44) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6897168 | 0.87 | PLA2G1B (0.44) | HSP90AA1HPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |