Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896346 | 0.92 | SLC6A3 (0.41) | PTGDR2HSP90AA1HSP90B1HPGDALDH1A1 | |
| SCHEMBL6891733 | 0.89 | MAPT (0.43) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6894747 | 0.89 | PLA2G2A (0.44) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6894986 | 0.89 | HSP90AA1 (0.38) | PTGDR2HSP90AA1HSP90B1HPGDALDH1A1 | |
| SCHEMBL6888996 | 0.88 | TSHR (0.46) | PTGDR2HSP90AA1HSP90B1HPGDALDH1A1 | |
| SCHEMBL6894204 | 0.88 | L3MBTL1 (0.44) | HSP90AA1HSP90B1ALDH1A1MEN1KMT2A | |
| SCHEMBL6894916 | 0.88 | MAPT (0.45) | HSP90AA1HSP90B1HPGDALDH1A1MEN1 | |
| SCHEMBL6892130 | 0.88 | HSP90AA1 (0.38) | PTGDR2HSP90AA1HSP90B1HPGDALDH1A1 | |
| SCHEMBL6782214 | 0.88 | PARP1 (0.39) | MAPK8FEN1 | |
| SCHEMBL6694644 | 0.87 | AR (0.45) | ALDH1A1MEN1KMT2AKDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |