SCHEMBL6892256

SCHEMBL6892256

NC(=S)CCc1ccc(F)cc1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.52
MAOB P27338 2/20 0.52
AOC3 Q16853 2/20 0.52
AOC2 O75106 1/20 0.52
MAOA P21397 1/20 0.52
FFAR1 O14842 1/20 0.46
PLA2G1B P04054 2/20 0.45
ATG4B Q9Y4P1 2/20 0.45
LOXL2 Q9Y4K0 1/20 0.44
IDO1 P14902 2/20 0.44
SLC5A1 P13866 1/20 0.43
SLC5A2 P31639 1/20 0.43
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6895380 0.81 PTGS1 (0.43) TAAR1MAOBAOC3AOC2MAOA
SCHEMBL11260863 0.80 FFAR1 (0.52) TAAR1MAOBAOC3AOC2MAOA
SCHEMBL4843038 0.78 IDO1 (0.53) TAAR1MAOBAOC3AOC2MAOA
SCHEMBL13349456 0.78 TAAR1 (0.52) TAAR1MAOBAOC3AOC2MAOA
SCHEMBL2466699 0.78 FFAR1 (0.55) TAAR1MAOBAOC3AOC2MAOA
SCHEMBL6894446 0.78 IDO1 (0.58) TAAR1MAOBAOC3FFAR1IDO1
SCHEMBL18003011 0.78 TAAR1 (0.57) TAAR1MAOBFFAR1IDO1
SCHEMBL6895007 0.77 PLA2G1B (0.48) TAAR1PLA2G1BATG4BLOXL2IDO1
SCHEMBL3651336 0.77 KEAP1 (0.54) TAAR1MAOBMAOAFFAR1LOXL2
Hydrochloric Acid SCHEMBL4714243 0.77 IDO1 (0.55) TAAR1MAOBAOC3AOC2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP claimed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP claimed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO claimed