Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.33 |
| ▸ | KYNU | Q16719 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399774 | 0.89 | OPRM1 (0.42) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL6395098 | 0.82 | ADRB1 (0.42) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL6396445 | 0.80 | OPRM1 (0.42) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL6394496 | 0.78 | ESR1 (0.45) | ADRA1ADRD1DRD3SLC6A3LMNA | |
| SCHEMBL6403806 | 0.77 | HIF1A (0.38) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL6396614 | 0.74 | SLC6A2 (0.37) | MIFNFKB1DRD1SLC6A3 | |
| SCHEMBL6399062 | 0.73 | ESR1 (0.33) | ESR1ESR2 | |
| SCHEMBL6402423 | 0.72 | ADRB1 (0.42) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL6395856 | 0.72 | ANPEP (0.41) | ADRB1MIFADRB2DRD1OPRM1 | |
| SCHEMBL6401536 | 0.71 | SLC22A1 (0.41) | ADRB1ADRA1AMIFHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787528-B2 | THERAPY FOR KIDNEY DISEASES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-09-07 | — | — | US | disclosed |