Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 3/20 | 0.34 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025318 | 0.85 | NCF1 (0.51) | MEN1KMT2ANCF1PKMMAPT | |
| SCHEMBL6893162 | 0.74 | KDM4E (0.47) | MEN1KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL5028713 | 0.67 | NCF1 (0.52) | MEN1KMT2ANCF1PKMMAPT | |
| SCHEMBL7039779 | 0.66 | FGFR1 (0.36) | NCF1PKMALDH1A1HSD17B10ALOX15 | |
| SCHEMBL5025396 | 0.64 | NCF1 (0.57) | MEN1KMT2ANCF1PKMMAPT | |
| SCHEMBL5022703 | 0.64 | NCF1 (0.51) | MEN1KMT2ANCF1PKMMAPT | |
| SCHEMBL5025304 | 0.63 | NCF1 (0.53) | MEN1KMT2ANCF1PKMALDH1A1 | |
| SCHEMBL3831791 | 0.61 | NCF1 (0.61) | MEN1KMT2ANCF1PKMNPSR1 | |
| SCHEMBL3833749 | 0.61 | NCF1 (0.61) | MEN1KMT2ANCF1PKMNPSR1 | |
| SCHEMBL5405074 | 0.61 | NCF1 (0.56) | MEN1KMT2ANCF1GBA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474145-A1 | QUINOLINE DERIVATIVES AS NPY ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | claimed |
| WO-2003066055-A1 | QUINOLINE DERIVATIVES AS NPY ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | claimed |