Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1502962 | 0.99 | GRM2 (0.59) | GRM2IGF1RALKCYP3A4DPP4 | |
| SCHEMBL1503174 | 0.88 | GRM2 (0.58) | GRM2IGF1RALK | |
| SCHEMBL6890122 | 0.88 | GRM2 (0.69) | GRM2CYP3A4 | |
| SCHEMBL6891800 | 0.82 | GRM2 (0.63) | GRM2CYP3A4 | |
| SCHEMBL6893676 | 0.81 | GRM2 (0.67) | GRM2CYP3A4 | |
| SCHEMBL6891956 | 0.80 | GRM2 (0.58) | GRM2CYP3A4 | |
| SCHEMBL6893000 | 0.79 | GRM2 (0.56) | GRM2CYP3A4 | |
| SCHEMBL1503021 | 0.78 | GRM2 (0.63) | GRM2CYP3A4 | |
| SCHEMBL1503074 | 0.78 | GRM2 (0.63) | GRM2CYP3A4 | |
| SCHEMBL6892975 | 0.77 | GRM2 (0.70) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |