Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 18/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 15/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10298617 | 0.82 | PRKACA (0.46) | OGFRL1OPRL1 | |
| SCHEMBL6895652 | 0.82 | CYP11B2 (0.39) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL10298620 | 0.78 | PRKACA (0.38) | OGFRL1OPRL1 | |
| SCHEMBL6896120 | 0.77 | USP30 (0.37) | — | |
| SCHEMBL6895803 | 0.74 | IDO1 (0.32) | OGFRL1OPRL1 | |
| SCHEMBL6895933 | 0.72 | DYRK1A (0.38) | — | |
| SCHEMBL6196431 | 0.67 | RPS6KB1 (0.58) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL21148134 | 0.67 | RPS6KB1 (0.58) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL18250748 | 0.67 | CCR5 (0.58) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL6198016 | 0.67 | RPS6KB1 (0.58) | OGFRL1OPRM1OPRK1OPRD1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011031818-A2 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2011-03-17 | — | — | WO | disclosed |