Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078615 | 0.79 | CYP3A4 (0.45) | RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7613137 | 0.79 | MEN1 (0.54) | HPGDMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7613129 | 0.79 | MEN1 (0.54) | HPGDMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL271177 | 0.76 | TRPM8 (0.47) | RAB9ANPC1 | |
| SCHEMBL609657 | 0.75 | BCHE (0.41) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL11343509 | 0.74 | HPGD (0.60) | HPGDMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5375742 | 0.73 | BACE1 (0.48) | — | |
| SCHEMBL1797388 | 0.71 | CYP3A4 (0.41) | ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL4357081 | 0.71 | CYP3A4 (0.50) | HPGDMEN1KMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8535483 | 0.70 | CTSD (0.47) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |