Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 7/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.44 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 known ✓ | P13945 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 7/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6805100 | 0.99 | HTR1A (0.44) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| SCHEMBL14571602 | 0.99 | HTR1A (0.45) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| SCHEMBL14571603 | 0.93 | DRD4 (0.46) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6804581 | 0.91 | DRD4 (0.45) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| SCHEMBL14571581 | 0.90 | HTR1A (0.46) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| Bromide SCHEMBL5585014 | 0.90 | MEN1 (0.41) | HTR1ASLC6A4DRD4DRD2 | |
| SCHEMBL14571526 | 0.90 | HTR1A (0.48) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| SCHEMBL5584477 | 0.90 | HTR1A (0.48) | HTR1ASLC6A4DRD4DRD2CYP1A2 | |
| SCHEMBL6809839 | 0.89 | MEN1 (0.42) | HTR1ASLC6A4DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL6802247 | 0.89 | HTR1A (0.45) | HTR1ASLC6A4DRD4DRD2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720320-B2 | ANTISEROTONINE AGENTS | MITSUBISHI PHARMA CORPORATION (JP) | 2004-04-13 | — | — | US | disclosed |
| US-20020111358-A1 | Phenoxypropylamine compounds | MITSUBISHI PHARMA CORPORATION (JP) | 2002-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111358-A1 | Phenoxypropylamine compounds | HTR1A, HTR1D, HTR5A | HTR1A 1/4885SLC6A4 10/4885ADRB2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.