Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 9/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.59 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.58 |
| ▸ | NADK | O95544 | 1/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101380 | 0.89 | AHCY (0.62) | AHCYPRMT5WDR77ADORA3NADK | |
| SCHEMBL800346 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL16300875 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL800381 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL13173634 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL18520788 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL22326787 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL21413837 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL22326785 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B | |
| SCHEMBL13134675 | 0.88 | PRMT5 (0.64) | AHCYPRMT5WDR77ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482977-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | AGOURON PHARMACEUTICALS INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2003074083-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | APRT, MTAP, TYMP | AHCY 62/4885PRMT5 585/4885WDR77 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.