SCHEMBL6894525

SCHEMBL6894525

CC[C@H](SC(C)=O)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.47
POLB P06746 1/20 0.40
TDP1 Q9NUW8 2/20 0.35
CHRM1 P11229 1/20 0.35
AKR1A1 P14550 1/20 0.35
CHRM3 P20309 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
ADRA1A P35348 1/20 0.35
HRH1 P35367 1/20 0.35
DRD3 P35462 1/20 0.35
SLC6A3 Q01959 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
CA2 P00918 1/20 0.34
MAPK1 P28482 1/20 0.34
SLC1A3 P43003 1/20 0.33
SLC1A2 P43004 1/20 0.33
SLC1A1 P43005 1/20 0.33
CPB2 Q96IY4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4457494 1.00 HTT (0.47) HTTPOLBTDP1CHRM1AKR1A1
SCHEMBL16478582 0.84 HTT (0.34) HTTTDP1ALDH1A1
SCHEMBL6889610 0.83 CHRM1 (0.46) HTTTDP1CHRM1AKR1A1CHRM3
SCHEMBL6889603 0.83 CHRM1 (0.46) HTTTDP1CHRM1AKR1A1CHRM3
SCHEMBL4885843 0.83 HTT (0.36) HTTPOLBSLC1A3SLC1A2SLC1A1
SCHEMBL233154 0.80 TDP1 (0.40) POLBTDP1ALDH1A1
SCHEMBL233153 0.80 TDP1 (0.40) POLBTDP1ALDH1A1
SCHEMBL6897326 0.80 CA2 (0.47) CA2MAPK1SLC1A3SLC1A2SLC1A1
SCHEMBL4428606 0.80 CA2 (0.47) CA2MAPK1SLC1A3SLC1A2SLC1A1
SCHEMBL4428605 0.80 CA2 (0.47) CA2MAPK1SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629627-B1 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL MYERS SQUIBB CO (US) 2004-05-06 EP disclosed
CN-1046525-C Compounds containing a fused bicyclic ring and processes therefor BRISTOL MYERS SQUIBB CO (US) 1999-11-17 CN disclosed
US-5756832-A REACTING AN ALDHYDE WITH AN ORTHOFORMATE IN THE PRESENCE OF AN ACID CATALYST AND AN ALCOHOL BRISTOL-MYERS SQUIBB CO. (US) 1998-05-26 US disclosed
US-5672599-A DUAL ACTION ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND NEUTRAL ENDOPEPTIDASE INHIBITORS; TREATMENT OF CARDIOVASCULAR DISORDERS BRISTOL-MYERS SQUIBB CO. (US) 1997-09-30 US disclosed
US-5670699-A Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring BRISTOL-MYERS SQUIBB CO. (US) 1997-09-23 US disclosed
US-5627278-A MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION BRISTOL-MYERS SQUIBB CO. (US) 1997-05-06 US disclosed
US-5616775-A ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE BRISTOL-MYERS SQUIBB CO. (US) 1997-04-01 US disclosed
US-5508272-A SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1996-04-16 US disclosed
CN-1099392-A Compounds containing a fused bicyclic ring and processes therefor BRISTOL MYERS SQIBB COMPANY (US) 1995-03-01 CN disclosed
EP-0629627-A2 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 1994-12-21 EP disclosed