Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232383 | 0.91 | HTR1A (0.52) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL5236133 | 0.89 | HTR1A (0.50) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL5236576 | 0.89 | MPO (0.52) | HTR1ASLC6A4MPO | |
| SCHEMBL6790780 | 0.88 | SLC6A4 (0.45) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL5236057 | 0.85 | HTR1A (0.50) | HTR1ASLC6A4MPO | |
| SCHEMBL5232373 | 0.84 | HTR1A (0.49) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL5234655 | 0.84 | HTR1A (0.49) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL5239419 | 0.84 | HTR1A (0.49) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL5235763 | 0.80 | HTR1A (0.51) | HTR1ASLC6A4MPO | |
| SCHEMBL5236500 | 0.79 | SLC6A4 (0.48) | HTR1ACYP3A4CYP2C8DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800637-B2 | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | WYETH | 2004-10-05 | — | — | US | disclosed |