⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10011229 | 0.81 | ADRA2A (0.44) | — | |
| SCHEMBL5685765 | 0.81 | GAA (0.40) | — | |
| SCHEMBL10396864 | 0.79 | MCL1 (0.39) | — | |
| SCHEMBL10012540 | 0.79 | ADRA2A (0.38) | — | |
| SCHEMBL2566244 | 0.78 | GAA (0.44) | — | |
| SCHEMBL9360984 | 0.77 | DGKA (0.43) | — | |
| SCHEMBL6830315 | 0.77 | — | — | |
| SCHEMBL28639403 | 0.77 | — | — | |
| SCHEMBL2521585 | 0.77 | — | — | |
| SCHEMBL10011125 | 0.77 | DGKA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104072498-A | Synthetic method for (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide | UNIV SHENYANG PHARMACEUTICAL | 2014-10-01 | — | — | CN | claimed |
| EP-3862431-B1 | METHOD FOR PRODUCING HAIRPIN SINGLE-STRAND RNA MOLECULES | TORAY INDUSTRIES (JP) | 2024-06-26 | — | — | EP | disclosed |
| CN-113788846-B | Tricyclic thiazolo [5,4-d ] pyrimidinone derivative and application thereof | 中国科学院新疆理化技术研究所 | 2023-05-02 | — | — | CN | disclosed |
| US-20210317495-A1 | METHOD OF PRODUCING HAIRPIN SINGLE-STRANDED RNA MOLECULES | TORAY INDUSTRIES, INC. (JP) | 2021-10-14 | — | — | US | disclosed |
| EP-3862431-A1 | METHOD FOR PRODUCING HAIRPIN SINGLE-STRAND RNA MOLECULES | Toray Industries, Inc. (JP) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020071407-A1 | METHOD FOR PRODUCING HAIRPIN SINGLE-STRAND RNA MOLECULES | 東レ株式会社 | 2020-04-09 | — | — | WO | disclosed |
| EP-3303366-A1 | DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF | Newbio Therapeutics Inc. (CN) | 2018-04-11 | — | — | EP | disclosed |
| CN-104072498-B | (R) synthetic method of N [5 (2 methoxyl group 2 phenyl acetyl) 1,4,5,6 nafoxidines also [3,4 c] pyrazoles 3 base] 4 (4 methyl piperazine 1 base) Benzoylamide | 沈阳药科大学 | 2016-12-28 | — | — | CN | disclosed |
| WO-2016192527-A1 | DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF | NEWBIO THERAPEUTICS, INC. (CN) | 2016-12-08 | — | — | WO | disclosed |
| CN-104072498-A | Synthetic method for (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide | UNIV SHENYANG PHARMACEUTICAL | 2014-10-01 | — | — | CN | disclosed |
| EP-2296040-A1 | Positive photosensitive composition | Fujifilm Corporation (JP) | 2011-03-16 | — | — | EP | disclosed |
| CN-101910057-A | Stabilization of hydroxylamine containing solutions and method for their preparation | EKC TECHNOLOGY INC | 2010-12-08 | — | — | CN | disclosed |
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |