Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983514 | 0.85 | HTR2B (0.50) | HTR2BLMNATP53MAPTHTT | |
| SCHEMBL1983513 | 0.85 | HTR2B (0.50) | HTR2BLMNATP53MAPTHTT | |
| SCHEMBL1982924 | 0.81 | HTR2B (0.46) | HTR2BLMNATP53MAPTHTT | |
| SCHEMBL1982922 | 0.81 | HTR2B (0.46) | HTR2BLMNATP53MAPTHTT | |
| SCHEMBL1981326 | 0.72 | DPP4 (0.42) | HTR2BLMNATLR7SMN1; SMN2TLR8 | |
| SCHEMBL1981327 | 0.72 | DPP4 (0.42) | HTR2BLMNATLR7SMN1; SMN2TLR8 | |
| SCHEMBL1299684 | 0.72 | HTR2B (0.79) | HTR2BSMN1; SMN2ALDH1A1USP2PDE10A | |
| SCHEMBL27878469 | 0.70 | TLR7 (0.37) | LMNATLR7SMN1; SMN2TLR8TLR9 | |
| SCHEMBL27878467 | 0.70 | TLR7 (0.37) | HTR2BLMNAMAPTTLR7SMN1; SMN2 | |
| SCHEMBL1980560 | 0.69 | CTSS (0.41) | LMNATLR7SMN1; SMN2TLR8TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075634-A1 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | disclosed |