Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463623 | 0.88 | FPR3 (0.48) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL1462901 | 0.80 | FPR3 (0.50) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL16495526 | 0.80 | FPR3 (0.45) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL6893858 | 0.80 | FPR3 (0.45) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL1462832 | 0.78 | FPR3 (0.44) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL1298827 | 0.77 | FPR3 (0.46) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL1298831 | 0.77 | FPR3 (0.46) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL1462724 | 0.77 | FPR3 (0.47) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL6894084 | 0.76 | FPR3 (0.41) | FPR3FPR2KMT2AALDH1A1USP30 | |
| SCHEMBL12810104 | 0.75 | FPR2 (0.62) | FPR3FPR2KMT2AALDH1A1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011031818-A2 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2011031816-A2 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2011-03-17 | — | — | WO | disclosed |