Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | RARB | P10826 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6901064 | 0.96 | HSD11B1 (0.34) | HSD11B1KDM4ERAB9AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6903360 | 0.92 | MEN1 (0.30) | MEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL6903340 | 0.90 | HSD11B1 (0.37) | HSD11B1KDM4ERAB9ARARBMEN1 | |
| Hydrochloric Acid SCHEMBL6903211 | 0.89 | KDM4E (0.32) | HSD11B1KDM4ERAB9ARARBHSD17B10 | |
| Hydrochloric Acid SCHEMBL6903746 | 0.89 | KDM4E (0.32) | HSD11B1KDM4ERAB9ARARBHSD17B10 | |
| Hydrochloric Acid SCHEMBL6904819 | 0.89 | PTAFR (0.32) | MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6902844 | 0.86 | HSD11B1 (0.36) | HSD11B1RARB | |
| Hydrochloric Acid SCHEMBL6896959 | 0.85 | NPC1 (0.31) | RAB9AALDH1A1MAPTSMN1; SMN2S1PR1 | |
| Hydrochloric Acid SCHEMBL6898606 | 0.85 | NPC1 (0.31) | RAB9AALDH1A1MAPTSMN1; SMN2S1PR1 | |
| Hydrochloric Acid SCHEMBL6903362 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |