Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790478 | 0.90 | MAPK14 (0.44) | MAPK14CYP19A1MEN1KMT2ANPC1 | |
| SCHEMBL6783577 | 0.82 | MAPK14 (0.44) | MAPK14CYP19A1MEN1KMT2ANPC1 | |
| SCHEMBL6612309 | 0.82 | MAPK14 (0.54) | MAPK14CYP19A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL6768581 | 0.81 | MAPK14 (0.44) | MAPK14MAPTMEN1KMT2ANPC1 | |
| SCHEMBL6608972 | 0.80 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL6895717 | 0.78 | MKNK1 (0.42) | MAPK14CYP19A1MEN1KMT2APTGDR2 | |
| SCHEMBL6895721 | 0.78 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL6780701 | 0.75 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL6613288 | 0.74 | MAPK14 (0.54) | MAPK14CYP19A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL6773679 | 0.74 | MAPK14 (0.44) | MAPK14CYP19A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787555-B2 | SUCH AS 4-(4-FLUOROPHENYL)-5-(2-PHENYLMETHYLAMINO)PYRIMIDIN-4-YL)-1-ETHOXYMETHYL -(1,2,3)TRIAZOLE FOR INHIBITION OF RELEASE OF INFLAMMATORY INTERLEUKINS; FOR TREATMENT OF OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, AND CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY | 2004-09-07 | — | — | US | claimed |