Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | MYLK | Q15746 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790483 | 0.92 | DYRK1A (0.48) | MKNK1MAPK14KMT2ADYRK1ACLK4 | |
| SCHEMBL6783578 | 0.85 | DYRK1A (0.48) | MKNK1MAPK14KMT2ADYRK1ACLK4 | |
| SCHEMBL6608979 | 0.83 | MAPK14 (0.55) | MKNK1MAPK14 | |
| SCHEMBL6895721 | 0.82 | MAPK14 (0.54) | MAPK14DYRK1ACLK4 | |
| SCHEMBL6612309 | 0.80 | MAPK14 (0.54) | MAPK14CYP19A1 | |
| SCHEMBL6768581 | 0.79 | MAPK14 (0.44) | MAPK14MEN1KMT2A | |
| SCHEMBL6790478 | 0.78 | MAPK14 (0.44) | MAPK14MEN1KMT2ADYRK1ACDK2 | |
| SCHEMBL6780704 | 0.78 | MAPK14 (0.58) | MKNK1MAPK14CLK4CLK2 | |
| SCHEMBL6895713 | 0.78 | MAPK14 (0.43) | MAPK14MEN1KMT2ACYP19A1PTGDR2 | |
| SCHEMBL6781430 | 0.76 | MAPK14 (0.56) | MAPK14CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787555-B2 | SUCH AS 4-(4-FLUOROPHENYL)-5-(2-PHENYLMETHYLAMINO)PYRIMIDIN-4-YL)-1-ETHOXYMETHYL -(1,2,3)TRIAZOLE FOR INHIBITION OF RELEASE OF INFLAMMATORY INTERLEUKINS; FOR TREATMENT OF OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, AND CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY | 2004-09-07 | — | — | US | claimed |