Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790483 | 0.85 | DYRK1A (0.48) | MAPK14MAPK13MAPK9GSK3BDYRK1A | |
| SCHEMBL6895717 | 0.82 | MKNK1 (0.42) | MAPK14DYRK1ACLK4 | |
| SCHEMBL6790123 | 0.82 | MAPK14 (0.58) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL6612309 | 0.80 | MAPK14 (0.54) | MAPK14MAP4K4FRKMAPK9CSNK1D | |
| SCHEMBL6768581 | 0.79 | MAPK14 (0.44) | MAPK14 | |
| SCHEMBL6790478 | 0.78 | MAPK14 (0.44) | MAPK14GSK3BDYRK1A | |
| SCHEMBL6895713 | 0.78 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL6783578 | 0.78 | DYRK1A (0.48) | MAPK14MAPK13LCKMAPK9GSK3B | |
| SCHEMBL6783824 | 0.77 | MAPK14 (0.59) | MAPK14MAPK13PRKD3MAP4K4LCK | |
| SCHEMBL6783821 | 0.77 | MAPK14 (0.59) | MAPK14MAPK13PRKD3MAP4K4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787555-B2 | SUCH AS 4-(4-FLUOROPHENYL)-5-(2-PHENYLMETHYLAMINO)PYRIMIDIN-4-YL)-1-ETHOXYMETHYL -(1,2,3)TRIAZOLE FOR INHIBITION OF RELEASE OF INFLAMMATORY INTERLEUKINS; FOR TREATMENT OF OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, AND CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY | 2004-09-07 | — | — | US | claimed |