Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CASR | P41180 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887059 | 0.89 | TACR1 (0.50) | TACR1 | |
| SCHEMBL164926 | 0.86 | HTR2A (0.50) | KCNH2NR3C2LMNACYP1A2CYP2D6 | |
| SCHEMBL6895745 | 0.86 | LMNA (0.47) | ALDH1A1CASRLMNAMAPK1HTT | |
| SCHEMBL6892550 | 0.84 | EPHX1 (0.45) | ALDH1A1CASRLMNAMAPK1HTT | |
| SCHEMBL6895808 | 0.84 | SMN1; SMN2 (0.57) | ALDH1A1LMNAMAPK1HTTNPSR1 | |
| SCHEMBL6887798 | 0.83 | GAA (0.45) | ALDH1A1LMNAMAPK1HTTNPSR1 | |
| SCHEMBL6894820 | 0.83 | CYP1A2 (0.60) | ALDH1A1NR3C2LMNAMAPK1HTT | |
| SCHEMBL6886251 | 0.81 | TDP1 (0.52) | ALDH1A1CASRLMNAMAPK1HTT | |
| SCHEMBL6892044 | 0.79 | LMNA (0.38) | ALDH1A1LMNAMAPK1HTTNPSR1 | |
| SCHEMBL6894577 | 0.78 | SMN1; SMN2 (0.40) | ALDH1A1LMNAMAPK1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |