Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 14/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22984000 | 0.83 | KDM4E (0.40) | KDM4EPOLA1STING1TAS1R3TAS1R1 | |
| SCHEMBL25504661 | 0.83 | KDM4E (0.40) | KDM4EPOLA1STING1TAS1R3TAS1R1 | |
| SCHEMBL12729604 | 0.81 | STING1 (0.46) | STING1 | |
| SCHEMBL8620596 | 0.81 | STING1 (0.46) | STING1 | |
| SCHEMBL17037317 | 0.78 | STING1 (0.49) | STING1 | |
| SCHEMBL21049964 | 0.78 | STING1 (0.49) | STING1 | |
| SCHEMBL6897814 | 0.77 | POLA1 (0.58) | KDM4EPOLA1 | |
| SCHEMBL12729593 | 0.74 | KDM4E (0.41) | KDM4EPOLA1TAS1R3TAS1R1 | |
| SCHEMBL8668421 | 0.72 | NT5E (0.36) | STING1 | |
| SCHEMBL12729601 | 0.71 | KDM4E (0.39) | KDM4EPOLA1STING1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604409-B1 | OLIGONUCLEOTIDE ANALOGS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS INC (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1418179-A2 | Compositions and methods for detecting and modulating rna activity and gene expression | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6262241-B1 | ANTISENSE COMPOUNDS WHICH CLEAVE PHOSPHORODIESTER BONDS AND IMPROVE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF OLIGONUCLEOTIDES, USEFUL IN DIAGNOSING DISEASES | ISIS PHARMACEUTICALS, INC. | 2001-07-17 | — | — | US | disclosed |