Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | NPY1R | P25929 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895828 | 0.92 | HTR6 (0.41) | PARP1HTR6CNR2 | |
| SCHEMBL6895417 | 0.82 | CNR2 (0.43) | PARP1HTR6CNR2 | |
| SCHEMBL27869259 | 0.79 | NPY1R (0.41) | NPY1RCNR2TP53 | |
| SCHEMBL10012212 | 0.79 | L3MBTL1 (0.39) | PARP1CNR2TP53MAPTL3MBTL1 | |
| SCHEMBL6894057 | 0.78 | PARP1 (0.39) | PARP1CNR2TP53MAPTL3MBTL1 | |
| SCHEMBL419017 | 0.77 | JAK2 (0.43) | PARP1CNR2TP53L3MBTL1RAB9A | |
| SCHEMBL10298659 | 0.76 | MAPT (0.41) | NPY1RCNR2MAPTSMN1; SMN2 | |
| SCHEMBL6896271 | 0.73 | PARP1 (0.37) | PARP1CNR2TP53MAPTRAB9A | |
| SCHEMBL6893814 | 0.73 | PARP1 (0.38) | PARP1CNR2TP53MAPTL3MBTL1 | |
| SCHEMBL10010656 | 0.72 | CNR2 (0.36) | PARP1CNR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011031818-A2 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2011031816-A2 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2011-03-17 | — | — | WO | disclosed |