SCHEMBL6897369

SCHEMBL6897369

O=CCCC(C(=O)O)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.68
POLB P06746 4/20 0.68
KDM4E B2RXH2 1/20 0.68
TP53 P04637 1/20 0.68
GLA P06280 1/20 0.68
CYP3A4 P08684 1/20 0.68
CYP2D6 P10635 1/20 0.68
HPGD P15428 1/20 0.68
ALOX12 P18054 1/20 0.68
NFKB1 P19838 1/20 0.68
APEX1 P27695 1/20 0.68
MAPK1 P28482 1/20 0.68
HSD17B10 Q99714 1/20 0.68
GAA P10253 2/20 0.60
L3MBTL1 Q9Y468 2/20 0.50
HIF1A Q16665 1/20 0.50
DNMT1 P26358 5/20 0.48
KMT2A Q03164 3/20 0.48
PKM P14618 2/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6897362 1.00 ALDH1A1 (0.68) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL7349189 0.91 ALDH1A1 (0.64) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL7349201 0.91 ALDH1A1 (0.64) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL21349847 0.86 ALDH1A1 (0.60) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL22698792 0.82 ALDH1A1 (0.47) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL10617336 0.82 ALDH1A1 (0.73) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL6896845 0.82 ALDH1A1 (0.79) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL6896852 0.82 ALDH1A1 (0.79) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL11589354 0.81 ALDH1A1 (0.71) ALDH1A1POLBKDM4ETP53GLA
SCHEMBL2888134 0.81 POLB (0.71) ALDH1A1POLBKDM4ETP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-58055459-A None JP disclosed
CN-101560204-B Antihypertensive drug cilazapril intermediate and preparation method thereof ZHEJIANG HUAHAI PHARM CO LTD 2013-11-13 CN disclosed
WO-2010093605-A1 ISOTOPOLOGUES OF THALIDOMIDE CELGENE CORPORATION (US) 2010-08-19 WO disclosed
CN-101560204-A Antihypertensive drug cilazapril intermediate and preparation method thereof ZHEJIANG HUAHAI PHARM CO LTD (CN) 2009-10-21 CN disclosed
EP-0629627-B1 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL MYERS SQUIBB CO (US) 2004-05-06 EP disclosed
WO-1999054321-A1 SUBSTITUTED DIAMINES AND THEIR USE AS CELL ADHESION INHIBITORS AVENTIS PHARMA LIMITED (GB) 1999-10-28 WO disclosed
US-5859239-A Mercaptoalkanoylamino and acylmercaptoalkanoylamino benzoxazepines and benzothiazepines E. R. SQUIBB & SONS, INC. (US) 1999-01-12 US disclosed
US-5856476-A Processes for preparing azepiones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutral endopeptidase E. R. SQUIBBS & SONS, INC. (US) 1999-01-05 US disclosed
US-5856477-A HYPOTENSIVE AGENTS; CONGESTIVE HEART FAILURE E. R. SQUIBB & SONS, INC. (US) 1999-01-05 US disclosed
US-5756832-A REACTING AN ALDHYDE WITH AN ORTHOFORMATE IN THE PRESENCE OF AN ACID CATALYST AND AN ALCOHOL BRISTOL-MYERS SQUIBB CO. (US) 1998-05-26 US disclosed
US-5672599-A DUAL ACTION ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND NEUTRAL ENDOPEPTIDASE INHIBITORS; TREATMENT OF CARDIOVASCULAR DISORDERS BRISTOL-MYERS SQUIBB CO. (US) 1997-09-30 US disclosed
US-5670699-A Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring BRISTOL-MYERS SQUIBB CO. (US) 1997-09-23 US disclosed
US-5654294-A CARDIOVASCULAR DISORDERS BRISTOL-MYERS SQUIBB (US) 1997-08-05 US disclosed
US-5646276-A ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS; CARDIOVASCULAR DISORDERS BRISTOL-MYERS SQUIBB CO. (US) 1997-07-08 US disclosed
US-5627278-A MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION BRISTOL-MYERS SQUIBB CO. (US) 1997-05-06 US disclosed
US-5616775-A ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE BRISTOL-MYERS SQUIBB CO. (US) 1997-04-01 US disclosed
US-5552397-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1996-09-03 US disclosed
US-5508272-A SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1996-04-16 US disclosed
EP-0629627-A2 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 1994-12-21 EP disclosed
JP-S5855459-A PREPARATION OF OPTICALLY ACTIVE TRYPTOPHAN DERIVATIVE DAI ICHI PURE CHEM CO LTD 1983-04-01 JP disclosed