Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | MGLL | Q99685 | 4/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6296853 | 0.89 | PPARG (0.58) | SMN1; SMN2PPARGPPARAMGLLFOLH1 | |
| SCHEMBL12646435 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2PPARGPPARAMGLL | |
| SCHEMBL5159161 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2PPARGPPARAFABP4 | |
| SCHEMBL4277047 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2PPARGPPARA | |
| SCHEMBL18668875 | 0.79 | GSK3B (0.48) | — | |
| SCHEMBL4651839 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2PPARGPPARA | |
| SCHEMBL295888 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2PPARGPPARA | |
| SCHEMBL2556069 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2PPARGPPARAFOLH1 | |
| SCHEMBL8935652 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2PPARGPPARAFOLH1FABP4 | |
| SCHEMBL826322 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2PPARGPPARAFOLH1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7973078-B2 | Sulfonamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |
| EP-1496838-B1 | SUBSTITUTED AMIDES | MERCK SHARP & DOHME (US) | 2010-11-03 | — | — | EP | disclosed |
| US-7396844-B1 | Benzamidine derivatives | AJINOMOTO CO., INC. (JP) | 2008-07-08 | — | — | US | disclosed |