Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.58 |
| ▸ | PPARA | Q07869 | 5/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 4/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689748 | 0.89 | SMN1; SMN2 (0.54) | PPARGPPARAFOLH1MGLLGPR34 | |
| SCHEMBL6297017 | 0.86 | PDCD1 (0.46) | PPARGPPARAMGLLFFAR1SMN1; SMN2 | |
| SCHEMBL20325399 | 0.81 | MGLL (0.42) | MGLLFFAR1MCHR1 | |
| SCHEMBL4273346 | 0.81 | PPARG (0.55) | PPARGPPARA | |
| SCHEMBL8935946 | 0.80 | PPARG (0.73) | PPARGPPARAPTGESALOX5 | |
| SCHEMBL5508320 | 0.80 | PPARG (0.73) | PPARGPPARAPTGESALOX5 | |
| SCHEMBL4798989 | 0.80 | PPARG (0.64) | PPARGPPARAFOLH1PTGESALOX5 | |
| SCHEMBL7255301 | 0.80 | PPARG (0.64) | PPARGPPARAFOLH1PTGESALOX5 | |
| SCHEMBL9978610 | 0.79 | FOLH1 (0.47) | PPARGPPARAFOLH1MGLLPTGES | |
| SCHEMBL6297030 | 0.77 | PPARG (0.57) | PPARGPPARAFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946489-B2 | Substituted biphenyl derivatives | MERCK PATENT GMBH (DE) | 2005-09-20 | — | — | US | disclosed |
| US-20040220241-A1 | Substituted biphenyl derivatives | MERCK PATENT GMBH (DE) | 2004-11-04 | — | — | US | disclosed |
| EP-1268413-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070678-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220241-A1 | Substituted biphenyl derivatives | APOB, F2R, BDKRB1 | PPARG 355/4885PPARA 158/4885FOLH1 3140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.