Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21900951 | 0.79 | PPARG (0.37) | LMNACA12CA1CA2CA9 | |
| SCHEMBL18723515 | 0.79 | CYP2D6 (0.41) | CYP2D6CYP3A4CYP1A2PRMT1LMNA | |
| SCHEMBL28525913 | 0.78 | CYP1A2 (0.38) | CYP2D6CYP3A4CYP1A2PRMT1CA12 | |
| SCHEMBL18962146 | 0.75 | CYP3A4 (0.46) | CYP2D6CYP3A4CYP1A2PRMT1LMNA | |
| SCHEMBL9366877 | 0.71 | TP53 (0.44) | CYP2D6CYP3A4CYP1A2PRMT1TAAR1 | |
| SCHEMBL30571169 | 0.71 | CYP2D6 (0.48) | CYP2D6CYP3A4CYP1A2PRMT1LMNA | |
| SCHEMBL5680420 | 0.70 | CYP2D6 (0.63) | CYP2D6CYP3A4CYP1A2PRMT1LMNA | |
| SCHEMBL9577412 | 0.70 | IDO1 (0.41) | CYP2D6CYP3A4CYP1A2PRMT1CA12 | |
| SCHEMBL8534443 | 0.70 | IDO1 (0.42) | CYP2D6CYP3A4CYP1A2PRMT1CA12 | |
| Hydrochloric Acid SCHEMBL11149712 | 0.70 | TP53 (0.42) | CYP2D6CYP3A4CYP1A2PRMT1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504391-B2 | Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders | SCHERING CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |
| EP-0845016-B1 | STABLE SILANE COMPOSITIONS ON SILICA CARRIER | GEN ELECTRIC (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6005027-A | ELASTOMER AND BLEND WITH SILANE AND SILICA AND INFRARED ABSORBANCE | WITCO CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0845016-A4 | STABLE SILANE COMPOSITIONS ON SILICA CARRIER | OSI SPECIALTIES INC (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0845016-A1 | STABLE SILANE COMPOSITIONS ON SILICA CARRIER | OSi Specialties, Inc. (US) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997007165-A1 | STABLE SILANE COMPOSITIONS ON SILICA CARRIER | OSI SPECIALTIES, INC. (US) | 1997-02-27 | — | — | WO | disclosed |