SCHEMBL18723515

SCHEMBL18723515

CC(C)(CCCl)NSCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP1A2 P05177 1/20 0.41
PRMT1 Q99873 1/20 0.41
LMNA P02545 1/20 0.40
SLC6A2 P23975 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
ALDH1A1 P00352 2/20 0.33
TRPA1 O75762 1/20 0.33
IDO1 P14902 3/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6897708 0.79 CYP2D6 (0.47) CYP2D6CYP3A4CYP1A2PRMT1LMNA
SCHEMBL28525913 0.71 CYP1A2 (0.38) CYP2D6CYP3A4CYP1A2PRMT1ALDH1A1
SCHEMBL15438998 0.68 CA1 (0.47) ALDH1A1
SCHEMBL18962146 0.68 CYP3A4 (0.46) CYP2D6CYP3A4CYP1A2PRMT1LMNA
SCHEMBL1839087 0.67 CYP3A4 (0.42) CYP2D6CYP3A4LMNASLC6A2TAAR1
SCHEMBL18723521 0.67 SIGMAR1 (0.39) CYP2D6CYP3A4CYP1A2SLC6A2TAAR1
SCHEMBL18723827 0.66 MAOA (0.38) SIGMAR1MAOA
Bromide SCHEMBL83856 0.66 CYP3A4 (0.41) CYP2D6CYP3A4LMNASLC6A2TAAR1
SCHEMBL9366877 0.65 TP53 (0.44) CYP2D6CYP3A4CYP1A2PRMT1TAAR1
SCHEMBL30571169 0.65 CYP2D6 (0.48) CYP2D6CYP3A4CYP1A2PRMT1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3319962-B1 ARYL SULTAM DERIVATIVES AS RORC MODULATORS HOFFMANN LA ROCHE (CH) 2020-05-13 EP disclosed
EP-3092239-B1 ARYL SULTAM DERIVATIVES AS RORC MODULATORS HOFFMANN LA ROCHE (CH) 2019-10-02 EP disclosed
EP-3010919-B1 ARYL SULTAM DERIVATIVES AS ROR-C MODULATORS HOFFMANN LA ROCHE (CH) 2017-04-12 EP disclosed