Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL889761 | 0.91 | EPHX1 (0.46) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL14725806 | 0.85 | EPHX1 (0.50) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL28439665 | 0.83 | CYP19A1 (0.35) | CYP19A1EPHX1NAAAHTTSMN1; SMN2 | |
| SCHEMBL11957261 | 0.81 | EPHX1 (0.38) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL4673658 | 0.80 | CYP19A1 (0.50) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL2182130 | 0.79 | CYP19A1 (0.53) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL28317353 | 0.79 | CYP19A1 (0.53) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL21677330 | 0.79 | NAAA (0.45) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL1164339 | 0.78 | CYP19A1 (0.41) | CYP19A1EPHX1NAAAHTTCYP2C19 | |
| SCHEMBL4679066 | 0.78 | CYP19A1 (0.51) | CYP19A1EPHX1NAAAHTTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008318-B2 | 39-desmethoxy derivatives of rapamycin | BIOTICA TECHNOLOGY LIMITED (GB) | 2011-08-30 | — | — | US | disclosed |
| WO-2011051960-A2 | PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES | CADILA HEALTHCARE LIMITED (IN) | 2011-05-05 | — | — | WO | disclosed |
| US-20100081682-A1 | 39-Desmethoxy Derivatives of Rapamycin | BIOTICA TECHNOLOGY LIMITED (GB) | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081682-A1 | 39-Desmethoxy Derivatives of Rapamycin | RICTOR, MTOR, MALT1 | CYP19A1 828/4885EPHX1 3598/4885NAAA 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.