Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561975 | 0.96 | TSHR (0.44) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| Potassium Ion SCHEMBL3660409 | 0.96 | TSHR (0.44) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| Lithium Ion SCHEMBL9625582 | 0.86 | TSHR (0.41) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| SCHEMBL34026 | 0.83 | TSHR (0.48) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| SCHEMBL28077512 | 0.83 | TSHR (0.48) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| SCHEMBL686652 | 0.83 | TSHR (0.41) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| Potassium Ion SCHEMBL5033981 | 0.83 | TSHR (0.41) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| SCHEMBL4613630 | 0.81 | TSHR (0.47) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| SCHEMBL30996180 | 0.79 | TSHR (0.44) | TSHRALDH1A1MAPK1TDP1TGM2 | |
| SCHEMBL29257467 | 0.78 | ZDHHC20 (0.45) | TSHRMAPK1TGM2ZDHHC20ZDHHC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6822065-B1 | THREE-DIMENSIONAL COPOLYMERS OF METHACRYLONITRILE AND CROSSLINKABLE COMONOMER OF GLYCIDYL ACRYLATE OR GLYCIDYL METHACRYLATE WITH METAL SALT ATTACHED; ELECTROCHEMICAL GENERATORS, ELECTROCHROMIC SYSTEMS OR CAPACITORS | INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE (FR) | 2004-11-23 | — | — | US | disclosed |