Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27481371 | 0.83 | MRGPRX4 (0.44) | KMT2AALDH1A1NPSR1CYP1A2CYP2C9 | |
| SCHEMBL2481833 | 0.81 | TSHR (0.44) | KMT2AALDH1A1NPSR1CYP1A2CYP2C9 | |
| SCHEMBL6064161 | 0.81 | CYP1A2 (0.60) | KMT2AALDH1A1NPSR1L3MBTL1CYP1A2 | |
| SCHEMBL6063458 | 0.77 | TSHR (0.44) | KMT2AALDH1A1NPSR1GRM7L3MBTL1 | |
| SCHEMBL5693370 | 0.76 | NPSR1 (0.50) | KMT2AALDH1A1NPSR1GRM7L3MBTL1 | |
| SCHEMBL5750409 | 0.75 | CYP1A2 (0.46) | KMT2AALDH1A1NPSR1GRM7L3MBTL1 | |
| SCHEMBL2086658 | 0.75 | CASP1 (0.47) | KMT2AALDH1A1NPSR1L3MBTL1ATM | |
| SCHEMBL5749360 | 0.74 | L3MBTL1 (0.45) | KMT2AALDH1A1NPSR1L3MBTL1ATM | |
| SCHEMBL24294928 | 0.72 | KDM4E (0.47) | KMT2AALDH1A1NPSR1GRM7L3MBTL1 | |
| SCHEMBL11801981 | 0.72 | CYP4F2 (0.63) | KMT2AALDH1A1NPSR1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476158-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | Pfizer Limited (GB) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068235-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |