SCHEMBL6898466

SCHEMBL6898466

CCO[C@](C)(C(=O)O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
CYP2D6 P10635 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP1A2 P05177 2/20 0.43
LMNA P02545 1/20 0.43
KMT2A Q03164 2/20 0.42
MAPT P10636 1/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
EDNRB P24530 1/20 0.42
EDNRA P25101 1/20 0.42
KCNN4 O15554 1/20 0.41
POLB P06746 2/20 0.41
ALDH1A1 P00352 3/20 0.41
ALOX15 P16050 1/20 0.41
CHRM2 P08172 1/20 0.41
CHRM4 P08173 1/20 0.41
CHRM5 P08912 1/20 0.41
CHRM1 P11229 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1670311 1.00 CYP2C19 (0.46) CYP2C19HIF1ACYP2D6CYP3A4CYP1A2
SCHEMBL5041181 0.90 CYP2C9 (0.49) LMNAMAPTPPARGPPARAALDH1A1
SCHEMBL5041186 0.90 CYP2C9 (0.49) LMNAMAPTPPARGPPARAALDH1A1
SCHEMBL4298978 0.87 LMNA (0.46) CYP2C19HIF1ACYP2D6CYP3A4CYP1A2
SCHEMBL6055984 0.85 ESR1 (0.50) CYP3A4LMNAALDH1A1CHRM2CHRM4
SCHEMBL6061648 0.85 ESR1 (0.50) CYP3A4LMNAALDH1A1CHRM2CHRM4
SCHEMBL3702043 0.85 PPARG (0.46) CYP2C19HIF1ACYP2D6CYP3A4CYP1A2
SCHEMBL13148475 0.84 CES1 (0.50) CYP2C19HIF1ACYP2D6CYP3A4CYP1A2
SCHEMBL7861200 0.84 PIN1 (0.50) CYP2C19HIF1ACYP2D6CYP3A4CYP1A2
SCHEMBL1678855 0.84 NPC1 (0.41) CYP2C19CYP3A4CYP1A2LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404309-A1 A PHARMACEUTICAL COMBINATION COMPRISING EITHER (S)-2-ETHOXY-3- 4-(2- 4-METHANE SULFONYL OXYPHENYL ETHOXY) PHENYL] PROPANOIC ACID OR 3- 4- 2- (4-TERT-BUTOXY CARBONYL AMINOPHENYL) ETHOXY] PHENYL -(S)-2-ETHOXY PROPANOIC ACID AND A BIGUANIDE DRUG AstraZeneca AB (SE) 2004-04-07 EP disclosed
EP-1401485-A1 A PHARMACEUTICAL COMBINATION COMPRISING EITHER (S)-2-ETHOXY-3 4-(2- 4-METHANE SULFONYL OXYPHENYL ETHOXY)PHENYL] PROPANOIC ACID OR 3- 4- 2- (4-TERT-BUTOXY CARBONYLAMINO PHENYL) ETHOXY] PHENYL -(S)-2-ETHOXY PROPANOIC ACID AND INSULIN AstraZeneca AB (SE) 2004-03-31 EP disclosed