Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.58 |
| ▸ | PARP14 | Q460N5 | 5/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | GRK3 | P35626 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689328 | 0.76 | MEN1 (0.51) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL21555689 | 0.74 | PARP1 (0.48) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL11283115 | 0.73 | PARP1 (0.52) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL5534554 | 0.72 | NPSR1 (0.76) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL29528287 | 0.72 | NPSR1 (0.76) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL8294937 | 0.72 | MEN1 (0.57) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL9448456 | 0.72 | PARP1 (0.51) | PARP1PARP10PARP14PARP15MEN1 | |
| SCHEMBL4485291 | 0.71 | PARP14 (0.47) | PARP1PARP10PARP14PARP15MEN1 | |
| Hydrochloric Acid SCHEMBL27681406 | 0.71 | MEN1 (0.56) | PARP1PARP10PARP14PARP15MEN1 | |
| Hydrochloric Acid SCHEMBL27700569 | 0.71 | MEN1 (0.56) | PARP1PARP10PARP14PARP15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |