Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736781 | 0.94 | TUBB1 (0.40) | MAPTL3MBTL1HPGDLMNAMAPK1 | |
| SCHEMBL2589218 | 0.86 | PDE4D (0.41) | MAPTL3MBTL1HPGDLMNAMAPK1 | |
| SCHEMBL2588591 | 0.85 | MAPT (0.34) | MAPTL3MBTL1HPGDLMNAMAPK1 | |
| SCHEMBL2591598 | 0.84 | ERN1 (0.47) | MAPTHPGDLMNAMAPK1TUBB1 | |
| SCHEMBL7942502 | 0.83 | SMN1; SMN2 (0.50) | MAPTL3MBTL1HPGDLMNAMAPK1 | |
| SCHEMBL2583910 | 0.82 | NCOA1 (0.40) | MAPTL3MBTL1HPGDLMNAMAPK1 | |
| SCHEMBL2591433 | 0.79 | ALOX5AP (0.34) | MAPTHPGDTUBB1PTPN1F2RL3 | |
| SCHEMBL2589018 | 0.78 | BACE1 (0.35) | TUBB1NQO2TDP1PTPN1F2RL3 | |
| SCHEMBL31166726 | 0.78 | ALOX5AP (0.35) | MAPTKDM4EPTPN1ALDH1A1F2RL3 | |
| SCHEMBL23041040 | 0.77 | MEN1 (0.43) | MAPTL3MBTL1MAPK1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777578-B2 | INHIBITOR OF TUBULIN POLYMERIZATION; ANTINEOPLASTIC ACTIVITY | ARIZONA BOARD OF REGENTS | 2004-08-17 | — | — | US | disclosed |
| US-20030220304-A1 | Hydroxyphenstatin and the prodrugs thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220304-A1 | Hydroxyphenstatin and the prodrugs thereof | TK1, TUBB8, PHPT1 | MAPT 452/4885L3MBTL1 114/4885HPGD 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.