TUBB8

Tubulin beta-8 chain · Q3ZCM7 · TUBB8 on Sugi Atlas →

133,835 patent compounds predicted against TUBB8, 84,882 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Curacin A Curacin A (SCHEMBL61304) 1.00 20/20
Vintriptol Vintriptol (SCHEMBL93959) 1.00 15/20
Vindesine Vindesine (SCHEMBL4420) 0.85 13/20
Vindesine Vindesine (SCHEMBL4421) 0.85 13/20
Vindesine Vindesine (SCHEMBL4285) 0.85 12/20
SCHEMBL147173 SCHEMBL147173 0.50 12/20
SCHEMBL147174 SCHEMBL147174 0.50 12/20
Combretastatin Combretastatin (SCHEMBL19955) 1.00 9/20
Combretastatin Combretastatin (SCHEMBL19956) 1.00 9/20
SCHEMBL118593 SCHEMBL118593 0.69 9/20
Centaureidin Centaureidin (SCHEMBL9953) 1.00 8/20
Thiocolchicine Thiocolchicine (SCHEMBL43160) 1.00 8/20
Thiocolchicine Thiocolchicine (SCHEMBL43161) 1.00 8/20
SCHEMBL68067 SCHEMBL68067 0.62 8/20
Fosbretabulin Fosbretabulin (SCHEMBL66079) 0.61 8/20
Vinorelbine Vinorelbine (SCHEMBL4765) 1.00 7/20
Combretastatin A4 Combretastatin A4 (SCHEMBL18945) 1.00 7/20
Combretastatin A4 Combretastatin A4 (SCHEMBL18946) 1.00 7/20
Levofloxacin Anhydrous Levofloxacin Anhydrous (SCHEMBL15397) 0.98 7/20
Ofloxacin Ofloxacin (SCHEMBL24373) 0.98 7/20

Clinical trials — most relevant to TUBB8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparative Analysis of the Efficacies in Neoadjuvant Chemotherapy of Breast Cancer PHASE3COMPLETED
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) PHASE2/PHASE3ACTIVE_NOT_RECRUITING
Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer PHASE2UNKNOWN
Biologic Correlative Taxotere/AC PHASE2COMPLETED
Neoadjuvant Paclitaxel Plus Epirubicin Versus Vinorelbine Plus Epirubicin in Breast Cancer With TEKT4 Variations PHASE2COMPLETED
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer PHASE2COMPLETED
A Multicenter Study of NAP (AL-108) in Schizophrenia PHASE2COMPLETED
Therapy With Docetaxel and ZD1839 for Patients Who Have Advanced Breast Cancer PHASE2COMPLETED
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer PHASE1/PHASE2NOT_YET_RECRUITING
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Treating Patients With Advanced Solid Tumors, Breast Cancer or Recurrent Ovarian Cancer PHASE1COMPLETED
Exploratory Evaluation of [11C]MPC6827 EARLY_PHASE1COMPLETED
Diagnostic of Chemotherapy Induced Neuropathy in Children nanCOMPLETED
Generating Intervals of Reference FFor Early Life Brain Biomarkers. nanRECRUITING
Prostate Cancer Antigen 3 (PCA-3) Gene Project nanCOMPLETED
Mapping Disease Pathways for Biliary Atresia nanRECRUITING
Biomarkers in the Diagnosis and Prognosis of NAFLD nanRECRUITING
Myotubular Myopathy Genetic Testing Study nanCOMPLETED
Effect of Low Dose of Colchicine on Platelet Reactivity nanCOMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Importance of the Microtubule Cytoskeleton in Oocyte Competence nanCOMPLETED
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
Genetics of Primary Ciliary Dyskinesia nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Thermal Spa Treatment and Improvement of Primary Ciliary Dyskinesia nanRECRUITING
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants. nanUNKNOWN
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development nanCOMPLETED
PCD New Gene Discovery nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TUBB8 binder may also engage these)

ProteinNameSimilarity
P46265 1.000 P46265 →
Q4R4X8 1.000 Q4R4X8 →
P85108 1.000 P85108 →
TUBB2A Tubulin beta-2A chain 1.000 landscape →
TUBB2B Tubulin beta-2B chain 1.000 landscape →
Q6B856 1.000 Q6B856 →
Q3MHM5 1.000 Q3MHM5 →
P68372 1.000 P68372 →
Q2HJ81 1.000 Q2HJ81 →
P11833 1.000 P11833 →
Q27U48 1.000 Q27U48 →
P69893 1.000 P69893 →
P12456 1.000 P12456 →
Q6GLE7 1.000 Q6GLE7 →
O44388 1.000 O44388 →
Q8WP14 1.000 Q8WP14 →
Q5R943 1.000 Q5R943 →
O59837 1.000 O59837 →
P33127 1.000 P33127 →
P61858 1.000 P61858 →
P14140 1.000 P14140 →
TUBB4A Tubulin beta-4A chain 1.000 landscape →
Q91240 1.000 Q91240 →
TUBB8B Tubulin beta 8B 1.000 landscape →
Q9YHC3 1.000 Q9YHC3 →
Q767L7 1.000 Q767L7 →
Q2KJD0 1.000 Q2KJD0 →
P09244 1.000 P09244 →
P69895 1.000 P69895 →
P22013 1.000 P22013 →