SCHEMBL6899772

SCHEMBL6899772

CC(C)N(CCOc1cccc(NC(=O)c2ccc(Oc3ccccc3)cc2)c1)C(C)C

nearest known ligand 0.73

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 12/20 0.73
HTR2C P28335 1/20 0.58
NR1H4 Q96RI1 2/20 0.57
MAOB P27338 2/20 0.55
KDM1A O60341 1/20 0.55
THRB P10828 1/20 0.55
MAPK1 P28482 1/20 0.54
MEN1 O00255 1/20 0.53
MAPT P10636 1/20 0.53
KMT2A Q03164 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6925375 0.91 MCHR1 (0.78) MCHR1HTR2CMAOBKDM1AMAPK1
SCHEMBL6807981 0.90 MCHR1 (0.83) MCHR1HTR2CMEN1KMT2A
SCHEMBL6811436 0.86 MCHR1 (0.75) MCHR1HTR2CMEN1KMT2A
SCHEMBL6899776 0.85 THRB (0.61) MCHR1NR1H4MAOBKDM1ATHRB
SCHEMBL6895261 0.85 MCHR1 (0.93) MCHR1HTR2C
SCHEMBL6926100 0.84 MCHR1 (0.64) MCHR1HTR2CTHRBMAPT
SCHEMBL6900340 0.83 MCHR1 (0.68) MCHR1HTR2CMEN1KMT2A
Iodomethane SCHEMBL6899429 0.83 MCHR1 (0.89) MCHR1HTR2C
SCHEMBL6928043 0.83 THRB (0.58) MCHR1NR1H4MAOBKDM1ATHRB
SCHEMBL6803781 0.81 MCHR1 (1.00) MCHR1HTR2CMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100485-A4 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-06-09 EP claimed
JP-2002521436-A 2002-07-16 JP claimed
EP-1100485-A1 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2001-05-23 EP claimed
WO-2000006146-A9 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2000-08-03 WO claimed
WO-2000006146-A1 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO claimed
EP-1100485-A4 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-06-09 EP disclosed
EP-1100485-A1 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2001-05-23 EP disclosed
WO-2000006146-A9 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2000-08-03 WO disclosed
WO-2000006146-A1 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed