Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925850 | 0.90 | MCHR1 (0.67) | THRBMCHR1NR1H4KMT2A | |
| SCHEMBL6925696 | 0.86 | THRB (0.62) | THRBNR1H4KDM1AMAOBPKM | |
| SCHEMBL6926029 | 0.83 | MCHR1 (0.55) | MCHR1KMT2ASMN1; SMN2 | |
| SCHEMBL6603858 | 0.83 | MCHR1 (0.71) | MCHR1 | |
| SCHEMBL6925375 | 0.83 | MCHR1 (0.78) | MCHR1KDM1AMAOB | |
| SCHEMBL6899772 | 0.83 | MCHR1 (0.73) | THRBMCHR1NR1H4KDM1AMAOB | |
| SCHEMBL6926100 | 0.80 | MCHR1 (0.64) | THRBMCHR1SMN1; SMN2 | |
| SCHEMBL6811436 | 0.77 | MCHR1 (0.75) | MCHR1KMT2A | |
| SCHEMBL16779951 | 0.77 | RXFP1 (0.81) | PKMHTTKMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL6925931 | 0.77 | MCHR1 (0.67) | THRBMCHR1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515027-B1 | Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 | SMITHKLINE BEECHAM CORP. | 2003-02-04 | — | — | US | disclosed |
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |