Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 4/20 | 0.67 |
| ▸ | SCN2A known ✓ | Q99250 | 4/20 | 0.67 |
| ▸ | SCN3A known ✓ | Q9NY46 | 4/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | MAOA | P21397 | 4/20 | 0.97 |
| ▸ | TSHR | P16473 | 4/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.97 |
| ▸ | HTR3A | P46098 | 2/20 | 0.97 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procaine SCHEMBL6337066 | 1.00 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL5311049 | 1.00 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL27720 | 1.00 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL8533022 | 1.00 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL3731588 | 1.00 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL9543344 | 0.98 | BLM (0.97) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL28225045 | 0.98 | BLM (0.97) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL3524 | 0.98 | CYP2D6 (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL11581374 | 0.97 | BLM (0.94) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL3422994 | 0.97 | CYP2D6 (0.97) | BLMNPSR1CYP2D6MAOATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004032916-A1 | A COMPOSITION COMPRISING SELEGELINE, PROCAINE, VINPOCETINE, TRIMETHYLGLYCINEAN AND A N-GABA INGREDIENT FOR TREATING NEURODEGENERATIVE DISORDERS | UNIFUND CORPORATION LIMITED (GB) | 2004-04-22 | — | — | WO | disclosed |