Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 4/20 | 0.65 |
| ▸ | SCN2A known ✓ | Q99250 | 4/20 | 0.65 |
| ▸ | SCN3A known ✓ | Q9NY46 | 4/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.94 |
| ▸ | MAOA | P21397 | 4/20 | 0.94 |
| ▸ | TSHR | P16473 | 4/20 | 0.94 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.94 |
| ▸ | HTR3A | P46098 | 2/20 | 0.94 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procaine SCHEMBL8533022 | 0.98 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL6901191 | 0.98 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL6337066 | 0.98 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL3731588 | 0.98 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL11047275 | 0.98 | CYP2D6 (0.97) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL5311049 | 0.98 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL27720 | 0.98 | BLM (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL28225045 | 0.97 | BLM (0.97) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL3524 | 0.97 | CYP2D6 (1.00) | BLMNPSR1CYP2D6MAOATSHR | |
| Procaine SCHEMBL11581374 | 0.95 | BLM (0.94) | BLMNPSR1CYP2D6MAOATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1116900-C | Solvent and external preparation containing the same | HISAMITSU PHARMACEUTICAL CO (JP) | 2003-08-06 | — | — | CN | claimed |
| CN-1116900-C | Solvent and external preparation containing the same | HISAMITSU PHARMACEUTICAL CO (JP) | 2003-08-06 | — | — | CN | disclosed |
| CN-1124014-A | Solubilizing agent and external preparation containing the same | HISAMITSU PHARMACEUTICAL CO (JP) | 1996-06-05 | — | — | CN | disclosed |
| WO-1993010687-A1 | HIGHLIGHTING PREPARATION AND METHOD OF USE | KINGSTONE KAREN (GB) | 1993-06-10 | — | — | WO | disclosed |