Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 5/20 | 0.67 |
| ▸ | SCN2A known ✓ | Q99250 | 5/20 | 0.67 |
| ▸ | SCN3A known ✓ | Q9NY46 | 5/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.97 |
| ▸ | TSHR | P16473 | 5/20 | 0.97 |
| ▸ | MAOA | P21397 | 4/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.97 |
| ▸ | HTR3A | P46098 | 2/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.94 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procaine SCHEMBL9050778 | 1.00 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL28225045 | 0.98 | BLM (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL3524 | 0.98 | CYP2D6 (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL28225044 | 0.97 | CYP2D6 (0.91) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL5311049 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL11047275 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL27720 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL28977033 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL6061234 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL3731588 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8828696-B2 | Use of Penicillin G Procaine as a selective antimicrobial agent in the production of alcohol by fermentation | Lallemand Specialites, Inc (US) | 2014-09-09 | — | — | US | disclosed |
| US-20100143307-A1 | Use of Penicillin G Procaine as a selective antimicrobial agent in the production of alcohol by fermentation | LALLEMAND SPECIALITIES, INC. | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143307-A1 | Use of Penicillin G Procaine as a selective antimicrobial agent in the production of alcohol by fermentation | GMPS, CUTA, RNGTT | SCN1A 856/4885SCN2A 762/4885SCN3A 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.