Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901788 | 0.84 | ESR1 (0.51) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL7954544 | 0.83 | ESR1 (0.44) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6898886 | 0.82 | ESR1 (0.43) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6895957 | 0.80 | ESR1 (0.62) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL7055576 | 0.79 | ESR1 (0.49) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6901001 | 0.79 | ESR1 (0.51) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL7056046 | 0.79 | ESR1 (0.51) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6895273 | 0.79 | ESR1 (0.44) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6899567 | 0.78 | ESR1 (0.46) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6895259 | 0.77 | ESR1 (0.57) | ESR1ESR2HTR2BTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465619-A1 | SUPPRESSION OF CARTILAGE DEGRADATION VIA THE ESTROGEN RECEPTOR | Nordic Bioscience A/S (DK) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003063859-A1 | SUPPRESSION OF CARTILAGE DEGRADATION VIA THE ESTROGEN RECEPTOR | NORDIC BIOSCIENCE A/S (DK) | 2003-08-07 | — | — | WO | disclosed |
| US-6043269-A | ESTROGEN AGONISTS | NOVO NORDISK A/S (DK) | 2000-03-28 | — | — | US | disclosed |
| EP-0937058-A1 | NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998018773-A1 | NOVEL CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-05-07 | — | — | WO | disclosed |