Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 1/20 | 0.55 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622574 | 0.85 | FABP4 (0.45) | TFPI2FABP4HTR2AHTR2CNOTUM | |
| SCHEMBL10837082 | 0.85 | NOTUM (0.59) | TFPI2FABP4HTR2AHTR2CNOTUM | |
| SCHEMBL17782560 | 0.82 | SNCA (0.46) | TFPI2MAPTRAB9AL3MBTL1THRB | |
| SCHEMBL5431558 | 0.82 | RAB9A (0.66) | TFPI2FABP4NOTUMMAPTTSHR | |
| SCHEMBL4175475 | 0.81 | TFPI2 (0.48) | TFPI2FABP4HTR2AHTR2CNOTUM | |
| SCHEMBL31517159 | 0.81 | TFPI2 (0.48) | TFPI2FABP4HTR2AHTR2CNOTUM | |
| SCHEMBL28400587 | 0.81 | TFPI2 (0.48) | TFPI2FABP4HTR2AHTR2CNOTUM | |
| SCHEMBL2116459 | 0.80 | TFPI2 (0.47) | TFPI2FABP4HTR2AHTR2CMAPT | |
| SCHEMBL14220747 | 0.78 | TFPI2 (0.62) | TFPI2FABP4HTR2AHTR2CMAPT | |
| SCHEMBL4379598 | 0.78 | MCL1 (0.47) | TFPI2FABP4HTR2AHTR2CNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392312-A1 | TRIAZOLO 4,5-d] PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002055083-A1 | TRIAZOLO[4,5-d] PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |