Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 2/20 | 0.59 |
| ▸ | AGXT | P21549 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 7/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | STAT1 | P42224 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29747227 | 1.00 | HCAR2 (0.60) | HCAR2IDO1AGXTMAOBPARP10 | |
| SCHEMBL4427972 | 0.88 | MAOB (0.71) | MAOBPARP10NR4A2 | |
| SCHEMBL9677464 | 0.87 | LMNA (0.48) | HCAR2MAOBPARP10MAPK1 | |
| SCHEMBL28707037 | 0.85 | HCAR2 (0.64) | HCAR2IDO1AGXTMAOBPARP10 | |
| SCHEMBL1787511 | 0.85 | HCAR2 (0.64) | HCAR2IDO1AGXTMAOBPARP10 | |
| SCHEMBL1787512 | 0.84 | HCAR2 (0.67) | HCAR2IDO1AGXTMAOBPARP10 | |
| SCHEMBL28321491 | 0.83 | TAAR1 (0.53) | HCAR2IDO1AGXTMAOBPARP10 | |
| SCHEMBL20493836 | 0.82 | AGXT (0.65) | HCAR2AGXTMAOBPARP10MMP1 | |
| SCHEMBL27795850 | 0.82 | LMNA (0.42) | HCAR2MAOBPARP10MMP1MMP2 | |
| SCHEMBL17011459 | 0.82 | IDO1 (0.59) | HCAR2IDO1AGXTMAOBPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115477634-B | Analgesic compounds and medical uses thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-02-13 | — | — | CN | disclosed |
| EP-4274569-A1 | C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER | Anima Biotech Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| CN-115477634-A | Compound for analgesia and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2022-12-16 | — | — | CN | disclosed |
| WO-2022150316-A1 | C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER | ANIMA BIOTECH INC. (US) | 2022-07-14 | — | — | WO | disclosed |
| CN-112159401-B | Biased agonist and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2022-06-03 | — | — | CN | disclosed |
| CN-112159401-A | Biased agonist and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2021-01-01 | — | — | CN | disclosed |
| US-10550112-B2 | Pyrimidines as EGFR inhibitors and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-04 | — | — | US | disclosed |
| CN-110506037-A | Aryl cyclopropyl-amino-isoquinolin amide compound | AERIE PHARMACEUTICALS INC | 2019-11-26 | — | — | CN | disclosed |
| CN-110073005-A | Method for detecting norovirus | 奎斯特诊断投资有限责任公司 | 2019-07-30 | — | — | CN | disclosed |
| US-20180194758-A1 | NOVEL PYRIMIDINES AS EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-07-12 | — | — | US | disclosed |
| EP-3325469-A1 | NOVEL PYRIMIDINES AS EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | Dana Farber Cancer Institute, Inc. (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017015363-A1 | NOVEL PYRIMIDINES AS EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-01-26 | — | — | WO | disclosed |
| EP-2755949-B1 | FUNGICIDAL 4-SUBSTITUTED-3-{PHENYL[(HETEROCYCLYLMETHOXY)IMINO]METHYL}-1,2,4-OXADIZOL-5(4H)-ONE DERIVATIVES | BAYER IP GMBH (DE) | 2015-10-21 | — | — | EP | disclosed |
| US-9090600-B2 | Fungicidal 4-substituted-3-{phenyl[(heterocyclylmethoxy)imino]methyl}-1,2,4-oxadizol-5(4H)-one derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-28 | — | — | US | disclosed |
| US-20140349848-A1 | FUNGICIDAL 4-SUBSTITUTED-3--1,2,4-OXADIZOL-5(4H)-ONE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349848-A1 | FUNGICIDAL 4-SUBSTITUTED-3--1,2,4-OXADIZOL-5(4H)-ONE DERIVATIVES | CYP4X1, CYP4B1, CYP4Z1 | HCAR2 2991/4885IDO1 112/4885AGXT 192/4885 |
| US-10550112-B2 | Pyrimidines as EGFR inhibitors and methods of treating disorders | EGFR, ERBB2, ERBB3 | HCAR2 2583/4885IDO1 2193/4885AGXT 482/4885 |
| US-20180194758-A1 | NOVEL PYRIMIDINES AS EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | EGFR, ERBB2, ERBB3 | HCAR2 3258/4885IDO1 2198/4885AGXT 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.