Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690060 | 0.86 | MAPK14 (0.53) | MAPK14SCARB1 | |
| Hydrochloric Acid SCHEMBL689965 | 0.85 | MAPK14 (0.52) | MAPK14SCARB1 | |
| SCHEMBL13458789 | 0.85 | MAPK14 (0.46) | MAPK14SCARB1EPHX2NR1H4LYN | |
| SCHEMBL2670913 | 0.83 | MAPK14 (0.40) | MAPK14SCARB1PIK3CAEPHX2NR1H4 | |
| SCHEMBL19047543 | 0.81 | MAPK14 (0.42) | MAPK14SCARB1PIK3CAEPHX2NR1H4 | |
| SCHEMBL690109 | 0.79 | SCARB1 (0.44) | MAPK14SCARB1ALDH1A1 | |
| SCHEMBL19047542 | 0.78 | MAPK14 (0.38) | MAPK14SCARB1PIK3CAEPHX2NR1H4 | |
| SCHEMBL690703 | 0.78 | KDM4E (0.46) | MAPK14ALDH1A1 | |
| SCHEMBL5311588 | 0.78 | MAPK14 (0.52) | MAPK14SCARB1 | |
| SCHEMBL16106349 | 0.77 | GSK3A (0.38) | MAPK14SCARB1PIK3CALYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |