Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690060 | 0.84 | MAPK14 (0.53) | SCARB1MAPK14BRAF | |
| Hydrochloric Acid SCHEMBL689965 | 0.83 | MAPK14 (0.52) | SCARB1MAPK14BRAF | |
| SCHEMBL721145 | 0.79 | LMNA (0.44) | SCARB1ALDH1A1MAPK14SRCSYK | |
| SCHEMBL689916 | 0.79 | ALDH1A1 (0.44) | SCARB1ALDH1A1MAPK14SRCSYK | |
| SCHEMBL690241 | 0.79 | MAPK14 (0.41) | SCARB1ALDH1A1MAPK14 | |
| SCHEMBL690623 | 0.76 | RARG (0.41) | ALDH1A1GSK3AKDM4EGAAMAPT | |
| SCHEMBL692574 | 0.76 | GSK3A (0.41) | SCARB1ALDH1A1MAPK14SRCSYK | |
| SCHEMBL16106403 | 0.76 | GSK3A (0.43) | SCARB1ALDH1A1MAPK14SRCSYK | |
| SCHEMBL690315 | 0.76 | MAPK14 (0.43) | SCARB1HSD17B10MAPK14 | |
| SCHEMBL22705390 | 0.75 | MAPK14 (0.46) | SCARB1ALDH1A1HSD17B10MAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |