Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29732929 | 1.00 | TDP1 (0.69) | TDP1AKR1B1CXCL8KDM4EGAA | |
| SCHEMBL21585561 | 0.93 | TDP1 (0.62) | TDP1AKR1B1CXCL8KDM4EGAA | |
| SCHEMBL29564952 | 0.90 | TDP1 (0.76) | TDP1AKR1B1CXCL8KDM4EGLA | |
| SCHEMBL69234 | 0.90 | TDP1 (0.76) | TDP1AKR1B1CXCL8KDM4EGLA | |
| SCHEMBL6741607 | 0.89 | AKR1B1 (0.61) | TDP1AKR1B1CXCL8KDM4EGAA | |
| SCHEMBL17537563 | 0.88 | TDP1 (0.56) | TDP1AKR1B1CXCL8KDM4EALDH1A1 | |
| SCHEMBL17537567 | 0.88 | TDP1 (0.56) | TDP1AKR1B1 | |
| SCHEMBL13912445 | 0.88 | TDP1 (0.56) | TDP1AKR1B1CXCL8KDM4EGAA | |
| SCHEMBL28776504 | 0.88 | TDP1 (0.56) | TDP1AKR1B1CXCL8PTGS1CAMK2A | |
| SCHEMBL694981 | 0.88 | TDP1 (0.56) | TDP1AKR1B1CXCL8KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114634615-B | Polycarbonate-polyester copolymer with low dielectric constant, high weather resistance and high impact resistance | 万华化学集团股份有限公司 | 2023-10-20 | — | — | CN | claimed |
| CN-116813473-A | Prepolymer, preparation method, michael addition coating with root inhibition effect and waterproof coating | 佛山市科顺建筑材料有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-114634615-A | Polycarbonate-polyester copolymer with low dielectric constant, high weather resistance and high impact resistance | 万华化学集团股份有限公司 | 2022-06-17 | — | — | CN | claimed |
| CN-116813473-B | Prepolymer, preparation method, michael addition coating with root inhibition effect and waterproof coating | 佛山市科顺建筑材料有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-114634615-B | Polycarbonate-polyester copolymer with low dielectric constant, high weather resistance and high impact resistance | 万华化学集团股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116813473-A | Prepolymer, preparation method, michael addition coating with root inhibition effect and waterproof coating | 佛山市科顺建筑材料有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-114634615-A | Polycarbonate-polyester copolymer with low dielectric constant, high weather resistance and high impact resistance | 万华化学集团股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| US-11220475-B2 | Monomers from biomass | NDSU RESEARCH FOUNDATION (US) | 2022-01-11 | — | — | US | disclosed |
| US-20210198175-A9 | NOVEL MONOMERS FROM BIOMASS | NDSU RESEARCH FOUNDATION (US) | 2021-07-01 | — | — | US | disclosed |
| US-20200140368-A1 | NOVEL MONOMERS FROM BIOMASS | NDSU RESEARCH FOUNDATION (US) | 2020-05-07 | — | — | US | disclosed |
| US-20180093939-A9 | NOVEL MONOMERS FROM BIOMASS | NDSU RESEARCH FOUNDATION (US) | 2018-04-05 | — | — | US | disclosed |
| CN-100357270-C | D-proline derivative | HOFFMANN LA ROCHE (CH) | 2007-12-26 | — | — | CN | disclosed |
| US-6740760-B2 | SUCH AS 1-((S)-3-MERCAPTO-2-METHYL-PROPIONYL)-(R)-PYRROL-IDINE-2-CARBOXYLIC ACID FOR TREATING DISEASES ASSOCIATED WITH AMYLOIDOSIS (ALZHEIMER'S DISEASE, DIABETES, AND FAMILIAL AMYLOID POLYNEUROPATHY) | HOFFMANN-LA ROCHE INC. | 2004-05-25 | — | — | US | disclosed |
| US-20030100770-A1 | Such as 1-((S)-3-mercapto-2-methyl-propionyl)-(R)-pyrrol-idine-2-carboxylic acid for treating diseases associated with amyloidosis (Alzheimer's disease, diabetes, and familial amyloid polyneuropathy) | PENTRAXIN THERAPEUTICS LTD. (GB) | 2003-05-29 | — | — | US | disclosed |
| US-6512001-B1 | To treat diseases associated with amyloidosis, such as Alzheimer's disease | HOFFMANN-LA ROCHE INC. | 2003-01-28 | — | — | US | disclosed |
| EP-0915088-B1 | D-Proline derivatives | HOFFMANN LA ROCHE (CH) | 2002-09-18 | — | — | EP | disclosed |
| US-6262089-B1 | USING THESE COMPOUNDS TO TREAT DISEASES ASSOCIATED WITH AMYLOIDOSIS, SUCH AS ALZHEIMER'S DISEASE, MATURITY ONSET DIABETES MELLITUS, FAMILIAL AMYLOID POLYNEUROPATHY, SCRAPIE, AND KREUZFELD-JACOB DISEASE. | HOFFMAN-LA ROCHE INC. | 2001-07-17 | — | — | US | disclosed |
| US-6103910-A | FOR TREATMENT OF DISEASES ASSOCIATED WITH AMYLOIDOSIS, SUCH AS ALZHEIMER'S DISEASE, DIABETES MELLITUS, FAMILIAL AMYLOID POLYNEUROPATHY, SCRAPIE, AND KREUZFELD-JACOB DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2000-08-15 | — | — | US | disclosed |
| CN-1217327-A | D-proline derivative | HOFFMANN LA ROCHE (CH) | 1999-05-26 | — | — | CN | disclosed |
| EP-0915088-A1 | D-Proline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100770-A1 | Such as 1-((S)-3-mercapto-2-methyl-propionyl)-(R)-pyrrol-idine-2-carboxylic acid for treating diseases associated with amyloidosis (Alzheimer's disease, diabetes, and familial amyloid polyneuropathy) | PSEN1, PSEN2, IAPP | TDP1 892/4885AKR1B1 34/4885CXCL8 4712/4885 |
| US-20210198175-A9 | NOVEL MONOMERS FROM BIOMASS | DCXR, MANBA, PGLS | TDP1 2448/4885AKR1B1 1678/4885CXCL8 3617/4885 |
| US-20180093939-A9 | NOVEL MONOMERS FROM BIOMASS | DCXR, MANBA, PGLS | TDP1 2448/4885AKR1B1 1678/4885CXCL8 3617/4885 |
| US-20200140368-A1 | NOVEL MONOMERS FROM BIOMASS | DCXR, MANBA, PGLS | TDP1 2448/4885AKR1B1 1678/4885CXCL8 3617/4885 |
| US-11220475-B2 | Monomers from biomass | DCXR, MGAM, ALG1 | TDP1 1471/4885AKR1B1 1227/4885CXCL8 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.