Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692913 | 0.90 | MAPK14 (0.42) | MAPK14SCARB1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL690060 | 0.86 | MAPK14 (0.53) | MAPK14SCARB1 | |
| Hydrochloric Acid SCHEMBL689965 | 0.85 | MAPK14 (0.52) | MAPK14SCARB1 | |
| SCHEMBL1935707 | 0.82 | MAPK14 (0.39) | MAPK14SCARB1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL5311588 | 0.77 | MAPK14 (0.52) | MAPK14SCARB1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL689060 | 0.75 | ADRB3 (0.39) | MAPK14SCARB1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4016327 | 0.74 | MAPK14 (0.54) | MAPK14SCARB1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4729217 | 0.74 | MAPK14 (0.57) | MAPK14SCARB1 | |
| SCHEMBL690241 | 0.73 | MAPK14 (0.41) | MAPK14SCARB1ALDH1A1EPHX2NR1H4 | |
| SCHEMBL689520 | 0.72 | ADRB3 (0.38) | MAPK14SMN1; SMN2KDM4EHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |