Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | BCHE | P06276 | 3/20 | 0.59 |
| ▸ | ACHE | P22303 | 3/20 | 0.59 |
| ▸ | BACE1 | P56817 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571134 | 0.92 | MEN1 (0.88) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL6517324 | 0.91 | MEN1 (0.61) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL14642000 | 0.91 | MEN1 (0.61) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL6023725 | 0.90 | MEN1 (0.68) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL22755777 | 0.90 | MEN1 (0.68) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL3598146 | 0.90 | MEN1 (0.68) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL25890035 | 0.86 | ACHE (0.60) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL20148958 | 0.86 | ACHE (0.60) | MEN1KMT2ABCHEACHEBACE1 | |
| SCHEMBL24240460 | 0.85 | MEN1 (0.55) | MEN1KMT2ABCHEACHEALDH1A1 | |
| SCHEMBL8844209 | 0.84 | MEN1 (0.57) | MEN1KMT2ABCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117551018-A | (R) -1-benzyl-3- (4-chlorophenyl) pyrrolidine-2, 5-dione and preparation method and application thereof | 宁夏医科大学 | 2024-02-13 | — | — | CN | disclosed |
| WO-2011073160-A1 | PYRROLIDINE DERIVATIVES AS NK - 3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |