SCHEMBL690306

SCHEMBL690306

COc1ccc(C=CC(=O)Oc2ccccc2C(=O)c2ccc(OC)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.54
MEN1 O00255 4/20 0.54
MAPT P10636 4/20 0.54
KDM4E B2RXH2 2/20 0.54
GAA P10253 1/20 0.54
F3 P13726 1/20 0.54
MAOB P27338 3/20 0.53
ALDH1A1 P00352 2/20 0.53
HSPD1 P10809 1/20 0.53
TNFRSF1A P19438 1/20 0.53
HSPE1 P61604 1/20 0.53
CYP1B1 Q16678 1/20 0.53
BCHE P06276 1/20 0.53
CYP3A4 P08684 1/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
MAOA P21397 2/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28716841 0.84 KMT2A (0.57) KMT2AMEN1MAPTKDM4EGAA
SCHEMBL29481400 0.83 KMT2A (0.55) KMT2AMEN1MAPTGAAMAOB
SCHEMBL8045874 0.82 MAPT (0.62) KMT2AMEN1MAPTKDM4EGAA
SCHEMBL10037013 0.81 KMT2A (0.59) KMT2AMEN1MAPTKDM4EF3
SCHEMBL29555131 0.81 KMT2A (0.59) KMT2AMEN1MAPTKDM4EF3
SCHEMBL689212 0.81 KMT2A (0.59) KMT2AMEN1MAPTKDM4EF3
SCHEMBL28113537 0.80 KMT2A (0.58) KMT2AMEN1MAPTF3MAOB
SCHEMBL10615199 0.79 ABCG2 (0.69) KMT2AMEN1MAPTF3MAOB
SCHEMBL10615205 0.79 ABCG2 (0.69) KMT2AMEN1MAPTF3MAOB
SCHEMBL7694732 0.79 KMT2A (0.69) KMT2AMEN1MAPTF3MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2192106-B1 ULTRAVIOLET ABSORBER LEAD CHEM CO LTD (JP) 2012-02-29 EP disclosed